Typically an increase of bone density was found, the compact part of long bones was coarsed, there were calcifications of the interosseous membrane between radius and ulna and some ossifications of the sacrospinal and sacrotuberous ligaments. In advanced cases, skeletal fluorosis causes painful damage to bones and joints. Skeletal Fluorosis is a chronic bone and joint disease caused by long term consumption of fluoride.. As fluoride accumulates in the bones it begins to negatively alter processes of bone formation and resorption- affecting the entire skeleton().Gradually bones become weaker and more brittle, while joints increase in pain and stiffness due to skeletal changes. • During later stages, calcification of the bones takes place, osteoporosis in long bones, and symptoms of osteosclerosis where the bones become denser and develop abnormal crystalline structure. Skeletal Fluorosis. It also affects the homeostasis o … All registration fields are required. Skeletal fluorosis is a bone disease caused by excessive accumulation of fluoride leading to weakened bones. Mudhir Sabir Shekha. Endemic skeletal fluorosis is a chronic metabolic bone and joint disease caused by ingesting large amounts of fluoride either through water or rarely from foods of endemic areas. Skeletal abnormalities were evaluated by using X-ray skiagraphy, estimating the Stage I–III of the skeletal fluorosis. Non-skeletal forms of fluorosis are earlier manifestations, which develop long before the onset of typical changes in teeth and skeletal bones these are seen as gastro-intestinal symptoms and may overlap with other diseases leading to misdiagnosis. Fluoride is a cumulative toxin which can alter accretion and resorption of bone tissue. What Is Skeletal Fluorosis? Severe forms of skeletal fluorosis results in marked disability. Skeletal fluorosis is a serious condition, resulting from chronic ingestion of large amounts of fluoride over many years during periods of bone modeling (growth) and/or remodeling. Registered users can save articles, searches, and manage email alerts. All Answers (5) 15th Jan, 2015. 2 Recommendations. Cite. The number of cases of coal-burning-type skeletal fluorosis has been estimated to be 1.5 million. Skeletal Fluorosis • Early stages of skeletal fluorosis start with pain in bones and joints, muscle weakness, sporadic pain, stiffness of joints and chronic fatigue. In skeletal fluorosis the bones are generally weaker than normal with stiffness and pain in …