Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. 22, 2018 - John Deanfield, Francesco Cosentino, Filip Knop - Online CME, 10' education - June 5, 2018 - Stefano Taddei, Cees Tack, Massimo Volpe - Online CME, 10' education - Mar. Della Badia LA, Elshourbagy NA, Mousa SA. Nat Commun. 2020. Get the latest public health information from CDC: https://www.coronavirus.gov.  |  Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ. A mechanism of action animation on the role of PCSK9 in the regulation of LDL cholesterol, This video is provided as an educational service by Amgen cardiovascular.  |  9, 2018 - VBWG at ACC, Orlando, FL, USA - Prof. Mardi Gomberg-Maitland, Falls Church, VA, USA - Online CME, 5' education - Aug. 29, 2017 - ESC 2017, Barcelona, Spain - Prof Nazzareno Galiè - Bologna, Italy, Literature - June 6, 2017 - Kylhammar D, et al. Literature - Oct. 6, 2020 - Camm AJ et al. Pharmacol Ther. 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Curr Atheroscler Rep. 2019 Mar 16;21(5):16. doi: 10.1007/s11883-019-0778-6. PCSK9 inhibitors – mechanisms of action. Disclosure. 28 PCSK9 Inhibitors – Pharmacology Video Lecturio - YouTube 29, 2020 - Profs. - J Am Heart Assoc. - Eur Heart J 2017, 3' education - Sep. 2, 2020 - Prof. Isabelle van Gelder, MD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Present perspectives and future horizons. 2020 Jun 26;11(1):3232. doi: 10.1038/s41467-020-17029-3. USA.gov. Atherosclerotic cardiovascular disease (ASCVD) is associated with significant morbidity and mortality worldwide. Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK. PathWest, Laboratory Medicine, Fiona Stanley Hospital, Perth . Epub 2020 Jan 10. 2020 Nov;313:126-136. doi: 10.1016/j.atherosclerosis.2020.09.008. NIH HHS A new class of drugs that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) has been developed to treat hyperlipidemia. Am J Lifestyle Med. 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Increased serum levels of low-density lipoprotein cholesterol (LDL-C) are an independent risk factor for ASCVD, and clinical trial data have shown that lowering LDL-C generally reduces cardiovascular risk. NLM Atherosclerosis. Less LDL receptors result in increased LDL-C in the bloodstream but inhibiting or binding the circulating PCSK9 results in increased LDL receptors with the resultant decrease in serum LDL-C. This site needs JavaScript to work properly. Clin Ther. Lecture - Apr. Physical Activity and Heart Failure: Taking Steps to Control a Major Public Health Burden. eCollection 2020 Nov-Dec. Iqbal Z, Ho JH, Adam S, France M, Syed A, Neely D, Rees A, Khatib R, Cegla J, Byrne C, Qureshi N, Capps N, Ferns G, Payne J, Schofield J, Nicholson K, Datta D, Pottle A, Halcox J, Krentz A, Durrington P, Soran H; Heart UK's Medical Scientific and Research Committee. 2016 Oct;26(10):853-62. doi: 10.1016/j.numecd.2016.05.006. 2013 Aug;35(8):1082-98. doi: 10.1016/j.clinthera.2013.06.019. COVID-19 is an emerging, rapidly evolving situation. JAMA Cardiol. Clipboard, Search History, and several other advanced features are temporarily unavailable. This video is provided as an educational service by Amgen cardiovascular This review discusses the history and mechanism of action of PCSK9 inhibitors, their metabolic effects, and clinical outcomes associated with these medications, highlighting recent large cardiovascular outcome trials investigating these therapies. In addition, adverse effects of statins may limit their tolerability and therefore the ability to attain effective doses in some patients. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Until recently, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been the main therapy for lowering LDL-C. PCSK9 inhibitor; cardiovascular disease; hyperlipidemia. Elife. 2016 Aug;164:183-94. doi: 10.1016/j.pharmthera.2016.04.011. 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