Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Therapies aimed at regulating autophagy are being developed. Cazzola M.| N Engl J Med 2020; 383:1358 … Bipolar disorder has a yearly prevalence of 2%. A common pathophysiological mechanism is autoimmunity. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. In many countries, a large majority of adults consume caffeine daily. 2 Notable Articles of 2018 ne.or Editorial The new england journal of medicine n engl j med 378;1 nejm.org January 4, 2018 81 Rewiring to Regain Function in Patients with Spastic Hemiplegia Robert J. Spinner, M.D., Alexander Y. Shin, M.D., and Allen T. Bishop, M.D. Other mental and physical conditions occur with bipolar disorder, which is also associated with an increased risk of suicide. This review focuses on CAH due to 21-hydroxylase deficiency. Except for del(5q) MDS, which is responsive to lenalidomide, these disorders are largely managed with supportive care. Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Sensory ganglionopathy is characterized by sensory loss without weakness. Degeneration of the elements of the cervical spine, which is almost inevitable with age, results in nerve-root and spinal cord compression and pain. This review focuses on acquired sensory ganglionopathies, most commonly seen in patients with an autoimmune disease or a paraneoplastic disorder. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. This review considers the cardiovascular consequences and strategies that can be used during acute kidney injury and recovery, with the aim of reducing subsequent cardiovascular risks. Guidelines for surveillance of the many associated medical problems and guidance for managing problems that are unique to Down syndrome are available. Esophageal motility disorders and esophageal reflux are common, produce a wide range of symptoms, and compromise quality of life. Surgical and conservative treatments are available. This review covers fibrotic pulmonary diseases. Most patients undergo surgery with or without radiation therapy. Atherosclerotic plaque rupture and erosion result in acute coronary syndromes. The trigeminal nerve and its projections to the intracranial vasculature — the trigeminovascular system — are at the nexus of migraine. This review summarizes the evidence about the varied physiological effects of caffeine and coffee and the risks of cardiovascular disease, insulin resistance, gallstones, cancer, and liver disease. Remdesivir and dexamethasone have benefits in hospitalized patients with severe Covid-19, but in patients with moderate disease, dexamethasone is not efficacious and data are insufficient to recommend for or against routine use of remdesivir. MDS are clonal hematopoietic disorders involving morphologic defects and peripheral-blood cytopenias, with a risk of progression to acute myeloid leukemia. Atherosclerotic plaque rupture and erosion result in acute coronary syndromes. Treatment of CLL, the most common leukemia in the West, has undergone a revolution in the past few years with the development of agents that target signaling kinases and cell-survival mediators. Identification of the mechanisms that trigger signals in this system have led to targeted treatments and preventive therapies for migraine. Oral contraceptives lower the risk by 30 to 40%. Down syndrome is phenotypically variable, but programs have been introduced to capitalize on each person’s best abilities. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. This review focuses on acquired sensory ganglionopathies, most commonly seen in patients with an autoimmune disease or a paraneoplastic disorder. … NEW! Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge. Trigeminal neuralgia is manifested by severe, paroxysmal facial pain. The authorized source of trusted medical research and education for the Chinese-language medical community. Treatment for patients with acute ischemic stroke is guided by the time from the onset of stroke, the severity of neurologic deficit, and findings on neuroimaging. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. The classical type involves compression of the trigeminal nerve root. NEJM Resident 360 Information, resources, and support needed to approach rotations - … Treatment of CLL, the most common leukemia in the West, has undergone a revolution in the past few years with the development of agents that target signaling kinases and cell-survival mediators. This review summarizes the evidence about the varied physiological effects of caffeine and coffee and the risks of cardiovascular disease, insulin resistance, gallstones, cancer, and liver disease. The authors review advances in developing durable immune tolerance. This review covers fibrotic pulmonary diseases. The classical type involves compression of the trigeminal nerve root. Inattentiveness and restlessness are improved more than quality-of-life measures in short-term trials. Information, resources, and support needed to approach rotations - and life as a resident. Identification of the mechanisms that trigger signals in this system have led to targeted treatments and preventive therapies for migraine. Improvements in diagnosis and treatment have improved the management of these disorders. Review Article Oct 01, 2020 Myelodysplastic Syndromes. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Survival even among patients with a poor prognosis now exceeds 8 years. Physical tests and imaging aid in determining the source of disability. The diagnosis of Covid-19 is usually based on SARS-CoV-2 PCR testing of a nasopharyngeal swab or other specimen. Review ArticleNov 19, 2020 Endometrial Cancer Lu K.H. MDS are clonal hematopoietic disorders involving morphologic defects and peripheral-blood cytopenias, with a risk of progression to acute myeloid leukemia. Physical tests and imaging aid in determining the source of disability. This review focuses on CAH due to 21-hydroxylase deficiency. The content of this site is intended for health care professionals. Therapies aimed at regulating autophagy are being developed. Early surgery is indicated in some patients. Reviewed are mechanisms and phenotypic features of plaque healing, its role in clinical events, and therapeutic implications.