Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Are there affects of drinking grapefruit juice while taking soma? Should I avoid certain foods while taking Lipitor? At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Moore has been published in "Family Circle" magazine and the "Milwaukee Sentinel" newspaper, along with numerous other national and regional magazines, daily and weekly newspapers and corporate publications. By OPINION
By MARIE … The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. Yes - that's fine. While Lipitor doesn't interact with blood oranges, it does interact with many over-the-counter supplements and medications, and a large number of prescription drugs. suzanne66 4 Sep 2011. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Orange juice also contains high amounts of vitamin C, folate and potassium. Talk with your doctor about any other substance you consider adding to your health regimen if you take Lipitor. Marleydog1 9 Dec 2017. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. While Lipitor doesn't interact with blood oranges, it does interact with many over-the-counter supplements and medications, and a large number of prescription drugs. Very Important. Research has shown that grapefruit disrupts the metabolism, or breakdown, of many medications, according to an article published in the August 15, 2006 issue of "American Family Physician." Will the pineapple juice interfere with the effectiveness of lipitor? This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. Answer this question. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Copyright © 2020 Leaf Group Ltd., all rights reserved. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. Zoloft & norethindrone & grapefruit soap Interaction? Please check with the appropriate physician regarding health questions and concerns. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Considerations. Like other varieties of oranges, blood oranges are citrus fruits. When a single 40 mg dose of atorvastatin was coadministered with 240 mL of grapefruit juice, atorvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 16% and 37%, respectively. Lipitor orange juice. Lipitor also lowers cholesterol and triglyceride blood levels. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. Learn More . Prune juice has long been known to help alleviate constipation. Dr. Savard says avoiding grapefruit juice is important as it can interfere with how the statin metabolizes in the body. If you are experiencing serious medical symptoms, seek emergency treatment immediately. Asked 4 Sep 2011 by Just want to know Updated 9 December 2017 Topics lipitor, pineapple. She has a Bachelor of Science in psychology. Answers (2) SU. Patients should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Should I avoid certain foods while taking Lipitor? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Different foods have adverse interactions with different medications. Side Effects of Grapefruit Seed Extract. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. An OJ a Day Keeps Cholesterol at Bay. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Promptly consult your doctor or pharmacist. There is 1 alcohol/food/lifestyle interaction with Lipitor (atorvastatin): Moderate Food Interaction Consumer information for this interaction is not currently available. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Featured on BlackDoctor There are some drugs on the market that come with a warning that states the patient should not take the medication if they also consume orange or other citrus juices (grapefruit, lemon, etc) because of the possibility of potentially dangerous interactions. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. Lipitor may negatively interact with grapefruit and certain other citrus fruits, and doctors recommend not eating these particular fruits or drinking their juice when taking Lipitor. Available for Android and iOS devices. MANAGEMENT: Patients receiving therapy with atorvastatin should limit their consumption of grapefruit juice to no more than 1 liter per day. For many years, doctors have recommended avoiding grapefruit while taking statins, but a study sponsored by the Florida Department of Citrus and published in the "British Journal of Clinical Pharmacology" in 2011 found only an insignificant interaction between grapefruit and Lipitor and no negative effects 3. This enzyme is essential for breaking down Lipitor and other statin drugs. Tangelos, a combination of tangerine and grapefruit, don't contain furanocoumarins, despite a portion of the end-product including genetic material from grapefruit 2. Atorvastatin, known as the brand Lipitor, is a prescription medication for preventing and treating heart disease. Grapefruit, Pomegranate Juice Not a Good Mix With Statins Pomegranate juice, like grapefruit juice, may pose health risks with drugs.